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SEMINAR: Statistical Models vs Machine Learning in Health Research [May 2nd; live streaming available]

The Dalla Lana School of Public Health at the University of Toronto will be hosting a public lecture by Prof. Frank E. Harrell Jr. on Thursday May 2, 2019 from 11am to 12 noon, 155 College St. Room HS574. The title of the talk is “Musings on Statistical Models vs Machine Learning in Health Research”.

Registration for the event is required. The talk will also be available to access remotely by live streaming. If you register to participate for the event remotely an access link will be forwarded to you closer to the event.

The link to the registration site is
https://www.eventbrite.ca/e/public-lecture-musings-on-statistical-models-vs-machine-learning-in-health-research-tickets-60574892133

Description

Health researchers and practicing clinicians are with increasing frequency hearing about machine learning (ML) and artificial intelligence applications. They, along with many statisticians, are unsure of when to use traditional statistical models (SM) as opposed to ML to solve analytical problems related to diagnosis, prognosis, treatment selection, and health outcomes. And many advocates of ML do not know enough about SM to be able to appropriately compare performance of SM and ML. ML experts are particularly prone to not grasp the impact of the choice of measures of predictive performance. In this talk I attempt to define what makes ML distinct from SM, and to define the characteristics of applications for which ML is likely to offer advantages over SM, and vice-versa. The talk will also touch on the vast difference between prediction and classification and how this leads to many misunderstandings in the ML world. Other topics to be covered include the minimum sample size needed for ML, and problems ML algorithms have with absolute predictive accuracy (calibration). Presented by Professor Frank E. Harrell, Department of Biostatistics, Vanderbilt University.

About the Instructor:
  • Professor and founding Chair of the Department of Biostatistics, Vanderbilt University School of Medicine, Nashville TN USA
  • PhD in Biostatistics from U. North Carolina
  • Extensive work in biomedical and pharmaceutical research
  • ASA Fellow and winner of the ASA WJ Dixon Award for Excellence in Statistical Consulting in 2014
  • Publications
  • Active on stats.stackexchange.com – see my posts here
  • Written several R packages including Hmisc and rms
  • Used R intensively since 1999 and am a member of the R Foundation
  • Author of Regression Modeling Strategies, 2nd Edition
  • Statistical knowledge outside the areas of regression modeling strategies and Bayes is in BBR
  • Expert Statistical Advisor to the Office of Biostatistics, Center for Drug Evaluation and Research, FDA

Cannabis Research in Priority Areas Team Grants

The Canadian Institutes of Health Research Institute of Cancer Research (ICR) and Institute of Neurosciences, Mental Health and Addiction (INMHA), in partnership with the Canadian Cancer Society, will support Research investigating the benefits and/or harms related to therapeutic use of cannabis in people living with cancer.

See CIHR grant page HERE

The Cannabis Research in Priority Areas Team Grants is expected to:

  • •Generate new scientific knowledge that will advance our understanding of the potential benefits and/or harms of cannabis and/or cannabis use, and impact policies and programs in this area
  • Encourage interdisciplinary collaborations, including from across health research and from domains outside of health research, and the sharing of data and resources
  • Enhancing capacity development and training in cannabis research
  • Connect to existing knowledge translation efforts across Canada, for example through MHCC or the Canadian Centre on Substance Use and Addiction (CCSA)

The maximum amount per grant is $300,000 per year for up to 5 years for a total of $1.5 million, per grant. $1.5 million is available to fund an application relevant to the Cancer Pool (sponsored by the Canadian Cancer Society, ICR, and INMHA).

LOI due date: May 15, 2019
LOI notice of decision: July 15, 2019
Full application deadline: October 8, 2019
Funding start date: January 1, 2020

All applications must be submitted through CIHR’s ResearchNet. For more information view the funding opportunity details on the CIHR website.

CIHR will be hosting webinar(s) to review with participants the requirements of this funding opportunity and to answer questions. To find out more information and to register, visit the Webinars page.

CCS/CIHR Cancer Survivorship Team Grants

www.cancer.ca/en/research/grants-and-awards/current-funding-opportunities/survivorship-team-grants/

The goal of the CCS/CIHR Cancer Survivorship Team Grant program is to improve the health outcomes for cancer survivors of all ages (pediatric, adolescent, young adult and adult) from the time of their cancer diagnosis until the time of their death or entry into palliative care. This program is not intended to focus on improving end-of-life care.

The intent of this funding opportunity is to support new intervention research designed to mitigate the challenges experienced along the survivorship journey, as well as the evaluation and validation of existing interventions to assess their potential for implementation as best practices.

The program goal will be achieved through the support of a network of multidisciplinary teams, each led by a nominated Principal Investigator and at least 2 co-Principal and/or co- Investigators, one of whom must be within their first five years as an independent researcher, drawn from at least 3 different regions of Canada (Atlantic Provinces, Central Canada, Prairie Provinces, West Coast, Northern Territories). Survivors and caregivers are expected to be engaged as full and active members of research teams.

Teams may request up to $500,000 per year for a maximum of $2,500,000 over a five-year period. Grants will be non-renewable. As the total budget for this competition is $10 million, it is anticipated that at least 4 teams will be funded in this competition. The engagement of additional partners may increase this number.

Registration due date: May 29, 2019
Relevance review results: mid-June, 2019
Full application deadline: September 10, 2019
Results announcement : November 2019
Anticipated start date: December 1, 2019

All applications must be submitted through the online application system (EGrAMS) by 5p.m. EST on the deadline date. Submissions will not be accepted beyond these times.

A Webinar is planned to explain the application process and overall objectives of the call. Applicants can register by sending an email at research@cancer.ca. Details for the April 8th, 2019 (@1pm EST) webinar will be provided in advance to interested applicants.

WEBINAR: Synoptic Pathology Reporting for Pediatric Patients with Hepatoblastoma

Please confirm your participation in this free webinar by April 1st, and register online, by visiting http://www.pogo.ca/education/synoptic-reporting/

On April 3, 2019, POGO is pleased to present an important professional development educational event in partnership with the Canadian Association of Pathologists (CAP-ACP) and the Canadian Partnership Against Cancer (CPAC).

The webinar “Synoptic Pathology Reporting for Pediatric Patients with Hepatoblastoma” will provide expert advice for advancing pediatric oncology through optimal pathology investigation, moving toward standardized reporting, and incremental clarity of clinical implications.

Date: Wednesday, April 3, 2019
Time: 1:00 – 2:30 p.m. (60 minutes presentation; 30 minutes Q & A)

Speaker: Dr. Dina El Demellawy, MD, PhD, FRCPC
Pediatric and Perinatal Pathologist, Children’s Hospital of Eastern Ontario (CHEO) Associate Professor, Department of Pathology and Laboratory Medicine Faculty of Medicine, University of Ottawa

Audience: Pathologists, Pathology Fellows and Residents;
Pediatric Oncologists, Surgeons, Radiation Oncologists; Clinical Research Associates (CRAs).

Learning Objectives:

  1. To review the CAP protocols related to Hepatoblastoma and its use by pathologists specializing in pediatric oncology.
  2. To understand changes in the latest revision of the CAP cancer protocols and electronic cancer checklists.

Participation details: Please confirm your participation in this free webinar by April 1st, by visiting http://www.pogo.ca/education/synoptic-reporting/ to register online.

For questions about registration, please contact Clara Jordan at cjordan@pogo.cacjordan@pogo.ca or 416-592-1232 ext. 237. Webinar login details will be provided in advance of the event.

Recording of LLSC WEBCAST now available – Children & Teens with Cancer: Challenges at School after Treatment


Speaker: Ann Klinck, M.A.Sc., C. Psych. Assoc., School Liaison, Pediatric Cancer School Support Program, Children’s Hospital, London Health Sciences Centre, Ontario

This training is useful for those who support children and teens during and after the cancer experience including parents, relatives, teachers, school support staff and nurses. The recording of this webcast can found on our Website at: www.llscanada.org/events/children-teens-with-cancer-challenges-at-school-after-treatment?src1=22346&src2=

Questions? Contact Fred Ho at The Leukemia & Lymphoma Society of Canada | fred.ho@lls.org | http://www.llscanada.org

CAR T-cell therapy webinar by Jim Whitlock recorded and available online (Canadian Cancer Survivor Network)

On June 1 Dr. Jim Whitlock (The Hospital for Sick Children) presented a webinar on CAR T-cell therapy.  This webinar was part of the Canadian Cancer Survivor Network seminar series and the recording is available online.

 

http://survivornet.ca/news/click-here-to-watch-our-most-recent-webinar-car-t-cell-therapy/

C17 Education webinar series: Cognitive and Neuroimaging Outcomes in Cognitive/Brain Rehabilitation Approaches by Donald Mabbott [30-May-2018 12pm MT]

The next C17 Educational Presentation will be held on: Wednesday, May 30th at 12:00 – 13:00 (MST).  Webinar details have been set to the sites – contact C17 for more information.

Presenter:  Donald J. Mabbott, Ph.D., C. Psych., ABPP  (Program Head, Neurosciences and Mental Health, Hospital for Sick Children)

Presentation Title:  Cognitive and Neuroimaging Outcomes in Cognitive/Brain Rehabilitation Approaches

Presentation Objectives:

  • Explore what quantitative neuro-imaging has allowed us to understand
  • Discuss how we have used different neuro-imaging approaches to characterize white matter structure and neural function in paediatric brain tumour survivors
  • Consider how the tissue properties of white matter structure may affect cognition in these children
  • Learn how white matter plasticity can be harnessed for brain repair and cognitive restoration in this vulnerable population of patients

CYP-C Research Champion Webinars: “Epidemiology of thrombo-embolism in children with cancer: a population-based study” (AKA an example of CYP-C data in use) 23-Mar-2018 12 EST

Topic: Epidemiology of thrombo-embolism in children with cancer: a population-based study
Presenter: Marie-Claude Pelland-Marcotte
Date: Friday, March 23, 2018
Time: 12:00 pm, Eastern Standard Time

For webinar information, contact Randy Barber in the C17 Office (randy.barber@AHS.ca)

This month’s webinar will be a change of pace, with results presented from a CYP-C data use application by Marie-Claude Pelland-Marcotte. Marie-Claude trained in Pediatric Hematology-Oncology from 2014 to 2017 in Toronto, at the Hospital for Sick Children and is currently doing a post-doctoral fellowship in Pediatric Hemostasis and Thrombosis. She is also undertaking a Master’s degree in Health Services Research at the University of Toronto. She will start a position as a staff hematologist in 2019 at the Centre Hospitalier Universitaire de Québec (Université Laval).

Past webinars are available on the C17 website under committees>CYP-C and  are linked below.


Research Champion Webinars (2018)

The objective of this webinar series is to provide members of the Canadian pediatric cancer community a broad understanding of how to access and utilize the Cancer in Young People in Canada data for research purposes. This series will include an overview of how to (1) develop an appropriate research question, (2) complete the data access process and (3) perform basic data manipulation and analysis using SAS and Microsoft Access. The webinars will be delivered once per month over the 2018 calendar year. We look forward to your participation!

CONFIRMED (2018; times are noon EST unless stated)
Institutional Reports (Feb 23)

FORTHCOMING (2018)
Flat File Reports
Data Manipulation in Access

Past
1. pdf-icon.gif Developing a Research Question – L Sung

2. pdf-icon.gif Overview and Requesting Data – S Badour, E Martineau, R Barber
video.JPG

3. pdf-icon.gif Power Literature Searching – E Uleryk    video.JPG
pdf-icon.gif Power Search PubMed [reference materials]

4. pdf-icon.gif Using SAS to analyze CYP-C data: An introduction – J Pole    video.JPG

5. pdf-icon.gif Using SAS to analyze CYP-C data: Advanced – J Pole    video.JPG

6. pdf-icon.gif Grant Writing Tips and Tricks – L Rosella    video.JPG

7. pdf-icon.gif SAS Procedures – J Pole    video.JPG

8. pdf-icon.gif Data Cleaning – G Giuseppe   video.JPG

9. pdf-icon.gif GIS for CYP-C Research – C Nielsen  video.JPG
excel.png Test Data [reference materials]

10. pdf-icon.gif SIOP2017 Census Geography – J Pole  video.JPG

11. pdf-icon.gif Data Analysis I – J Pole  video.JPG

12. pdf-icon.gif Data Analysis II – J Pole  video.JPG

Potential Publication Collaborations

1. Childhood cancer incidence in Canada: temporal, regional and deprivation-related patterns
2. Socioeconomic status and childhood cancer incidence
3. Association between socioeconomic characteristics and childhood cancer survival
4. Diagnostic and treatment intervals and childhood cancer survival: economic and distance dimensions
5. Incidence of relapse of childhood cancer (recurrence of the primary malignancy)
6. Health status/complications in survival of childhood cancer during 5 year follow-up
7. Subsequent malignancy rates of childhood cancer
8. Incidence and survival of childhood cancer in Canada**
9. Diagnostic and treatment intervals for pediatric cancer care in Canada
10. Completeness of case ascertainment of non-malignant CNS tumors in CYP-C
11. Access to care and survival of aboriginal children**
12. Spatial analysis of childhood cancer incidence**
13. Prognostic impact of demographic, histologic and therapeutic factors on childhood cancer survival in Canada
14. Childhood brain cancers: incidence and survival**
15. Health adjusted life expectancy (HALE) of childhood cancer
16. Obesity (BMI) and childhood cancer risk

**There are ongoing approved CYP-C projects in this area

CYP-C Research Champion Webinars: An Introduction to CYP-C Institutional Reports – AKA – How to access your own data!

Topic: An Introduction to CYP-C Institutional Reports – AKA – How to access your own data!

Date: Friday, February 23, 2018
Time: 12:00 pm, Eastern Standard Time
For webinar information, contact Randy Barber in the C17 Office (randy.barber@AHS.ca)


Research Champion Webinars (2018)

The objective of this webinar series is to provide members of the Canadian pediatric cancer community a broad understanding of how to access and utilize the Cancer in Young People in Canada data for research purposes. This series will include an overview of how to (1) develop an appropriate research question, (2) complete the data access process and (3) perform basic data manipulation and analysis using SAS and Microsoft Access. The webinars will be delivered once per month over the 2018 calendar year. We look forward to your participation!

Past webinars are available on the C17 website under committees>CYP-C

CONFIRMED (2018; times are noon EST unless stated)
Institutional Reports (Feb 23)

FORTHCOMING (2018)
Flat File Reports
Data Manipulation in Access

PAST

Past webinars are available on the C17 website under committees>CYP-C
1. pdf-icon.gif Developing a Research Question – L Sung

2. pdf-icon.gif Overview and Requesting Data – S Badour, E Martineau, R Barber
video.JPG 

3. pdf-icon.gif Power Literature Searching – E Uleryk    video.JPG 
pdf-icon.gif Power Search PubMed [reference materials]

4. pdf-icon.gif Using SAS to analyze CYP-C data: An introduction – J Pole    video.JPG 

5. pdf-icon.gif Using SAS to analyze CYP-C data: Advanced – J Pole    video.JPG 

6. pdf-icon.gif Grant Writing Tips and Tricks – L Rosella    video.JPG 

7. pdf-icon.gif SAS Procedures – J Pole    video.JPG 

8. pdf-icon.gif Data Cleaning – G Giuseppe   video.JPG 

9. pdf-icon.gif GIS for CYP-C Research – C Nielsen  video.JPG 
excel.png Test Data [reference materials]

10. pdf-icon.gif SIOP2017 Census Geography – J Pole  video.JPG  

11. pdf-icon.gif Data Analysis I – J Pole  video.JPG 

12. pdf-icon.gif Data Analysis II – J Pole  video.JPG 

Synoptic Reporting Webinar: Pediatric Patients with Ewing Sarcoma (22-Mar-2017, 1pm EST, free registration requi

Presented by:

Dr. Dina El Demellawy, MD, PhD, FRCPC
Pediatric Pathologist, Children’s Hospital of Eastern Ontario (CHEO)
Associate Professor, University of Ottawa and the University of Northern Ontario School of Medicine

Wednesday, March 22, 2017
1:00 – 2:30 p.m. EST (60 minutes presentation; 30 minutes Q & A)

Learning Objectives:

  1. To review the College of American Pathologists’ (CAP) protocols related to Ewing Sarcoma and its use by pathologists specializing in pediatric oncology.
  2. To understand changes in the latest revision of the CAP cancer protocols and electronic cancer checklists.

This webinar will provide expert advice for advancing pediatric oncology through optimal pathology investigation, moving toward standardized reporting, and incremental clarity of clinical implications.

Background:

As part of POGO’s long-range plan for childhood cancer in Ontario, a task force was initiated in 2012 to determine reporting protocols currently in use, to review/ generate/ approve reporting templates and conventions, and to recommend future practice in Ontario. The task force identified and endorsed the College of American Pathologists’ (CAP) Ewing Sarcoma protocol as the expert consensus-based approach to reporting and is recommending its adoption in Ontario. The task force is co-chaired by Dr. Joseph de Nanassy (Division Chief, Anatomical Pathology, Children’s Hospital of Eastern Ontario), Dr. Gino Somers (Head, Division of Pathology, Hospital for Sick Children) and Dr. David Malkin (POGO’s Medical Director from 2011-2016).

Participation details:

Please visit http://www.pogo.ca/education/synoptic-reporting/ to register for this free webinar. Webinar login details will be provided upon confirmation. Your registration by March 17 is suggested.

Questions? Contact Jamie Irvine, Assistant to the Conference & Educational Events Coordinator at jirvine@pogo.ca or 416-592-1232, ext. 227.